z-logo
Premium
Rhodium‐Catalyzed Chemodivergent Regio‐ and Enantioselective Allylic Alkylation of Indoles
Author(s) -
Sun Minghe,
Liu Min,
Li Changkun
Publication year - 2021
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202004613
Subject(s) - enantioselective synthesis , tsuji–trost reaction , chemoselectivity , rhodium , alkylation , electrophile , allylic rearrangement , chemistry , catalysis , indole test , ligand (biochemistry) , stereochemistry , medicinal chemistry , organic chemistry , receptor , biochemistry
The control of C3/N1 chemoselectivity in indole alkylation with the same electrophiles is still challenging. An Rh/bisoxazolinephosphane‐catalyzed chemodivergent regio‐ and enantioselective allylic alkylation of indoles was developed. Chiral C3‐ and N1‐allylindoles can be selectively obtained with high branched/linear ratio and up to 99 % ee by changing the counteranion of Rh, the allylic carbonate, the reaction temperature, and the ligand.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here