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seco ‐Labdanes: A Study of Terpenoid Structural Diversity Resulting from Biosynthetic C−C Bond Cleavage
Author(s) -
Grant Phillip S.,
Brimble Margaret A.
Publication year - 2021
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202004574
Subject(s) - cleavage (geology) , terpenoid , bond cleavage , chemistry , stereochemistry , biology , catalysis , organic chemistry , paleontology , fracture (geology)
Abstract The cleavage of a C−C bond is a complexity generating process, which complements oxidation and cyclisation events in the biosynthesis of terpenoids. This process leads to increased structural diversity in a cluster of related secondary metabolites by modification of the parent carbocyclic core. In this review, we highlight the diversifying effect of C−C bond cleavage by examining the literature related to seco ‐labdanes—a class of diterpenoids arising from such C−C bond cleavage events.