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Multi‐Step Continuous‐Flow Organic Synthesis: Opportunities and Challenges
Author(s) -
Jiao Jiao,
Nie Wenzheng,
Yu Tao,
Yang Fan,
Zhang Qian,
Aihemaiti Feierdaiweisi,
Yang Tingjun,
Liu Xuanyu,
Wang Jiachen,
Li Pengfei
Publication year - 2021
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202004477
Subject(s) - continuous flow , flow chemistry , biochemical engineering , computer science , nanotechnology , process engineering , organic synthesis , chemistry , materials science , engineering , organic chemistry , catalysis
Continuous‐flow multi‐step synthesis takes the advantages of microchannel flow chemistry and may transform the conventional multi‐step organic synthesis by using integrated synthetic systems. To realize the goal, however, innovative chemical methods and techniques are urgently required to meet the significant remaining challenges. In the past few years, by using green reactions, telescoped chemical design, and/or novel in‐line separation techniques, major and rapid advancement has been made in this direction. This minireview summarizes the most recent reports (2017–2020) on continuous‐flow synthesis of functional molecules. Notably, several complex active pharmaceutical ingredients (APIs) have been prepared by the continuous‐flow approach. Key technologies to the successes and remaining challenges are discussed. These results exemplified the feasibility of using modern continuous‐flow chemistry for complex synthetic targets, and bode well for the future development of integrated, automated artificial synthetic systems.