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A Nanoprobe Based on Gated Mesoporous Silica Nanoparticles for The Selective and Sensitive Detection of Benzene Metabolite t,t‐Muconic Acid in Urine
Author(s) -
Domínguez Marcia,
Blandez Juan F.,
LozanoTorres Beatriz,
Torre Cristina,
Licchelli Maurizio,
Mangano Carlo,
Amendola Valeria,
Sancenón Félix,
MartínezMáñez Ramón
Publication year - 2021
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202004272
Subject(s) - muconic acid , benzene , chemistry , nanoprobe , mesoporous silica , urine , chromatography , metabolite , nanoparticle , organic chemistry , nanotechnology , mesoporous material , materials science , biochemistry , catalysis
Benzene is a highly toxic aromatic hydrocarbon. Inhaling benzene can cause dizziness, vertigo, headaches, aplasia, mutations and, in the most extreme cases, cancer. Trans , trans ‐muconic acid (t,t‐MA) is one of the metabolization products of benzene. Although different analytical methods have been reported for the determination of t,t‐MA, these are often expensive, require trained personnel, are not suitable for on‐site measurements, and use hazardous organic solvents. For these reasons, the development of reliable, selective and sensitive methods for rapid and in situ detection of t,t‐MA are of importance. Addressing this challenge, a nanodevice for the selective and sensitive quantification of t,t‐MA in urine is reported. The nanodevice used is achieved using mesoporous silica nanoparticles loaded with a dye reporter and capped with a dicopper(II) azacryptand. Pore opening and payload release is induced rapidly (10 min) and selectively with t,t‐MA in urine, using a simple fluorimeter without sample pretreatment.