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Silica‐Supported Phosphine–Gold Complexes as an Efficient Catalytic System for a Dearomative Spirocyclization
Author(s) -
Cao Zhen,
Scalabre Antoine,
Nlate Sylvain,
Buffière Sonia,
Oda Reiko,
Pouget Emilie,
Bibal Brigitte
Publication year - 2021
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202004251
Subject(s) - catalysis , phosphine , trifluoromethanesulfonate , reactivity (psychology) , covalent bond , aryl , metal , chloride , chemistry , combinatorial chemistry , polymer chemistry , organic chemistry , alkyl , medicine , alternative medicine , pathology
The combination of metal catalyst and inorganic silica frameworks provides a greener approach to recyclable catalysis. In this study, three phosphine–gold chloride complexes have been successfully covalently grafted onto chiral silica nanohelices. The resulting 3D ensembles showed chiroptical properties that allowed the monitoring of the supported ligands. The heterogeneous gold chloride catalysts in cooperation with silver triflate exhibited high reactivity in various reactions, especially in the spirocyclization of aryl alkynoate esters, for which a catalytic loading of 0.05 mol % could be employed. The heterogeneous catalysts could be easily recovered and recycled seven or eight times without any loss of efficiency. By adding more silver triflate, 25 cycles with full conversion were achieved owing to a complex catalytic system based on silica and metallic species.