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Cover Feature: New Organometallic Ruthenium(II) Compounds Synergistically Show Cytotoxic, Antimetastatic and Antiangiogenic Activities for the Treatment of Metastatic Cancer (Chem. Eur. J. 66/2020)
Author(s) -
Wang Yuchen,
Jin Jiahui,
Shu Liwei,
Li Tongyu,
Lu Siming,
Subarkhan Mohamed Kasim Mohamed,
Chen Chao,
Wang Hangxiang
Publication year - 2020
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202004199
Subject(s) - ruthenium , cytotoxicity , cancer , chemistry , cover (algebra) , cancer research , combinatorial chemistry , stereochemistry , biology , biochemistry , engineering , genetics , mechanical engineering , in vitro , catalysis
Three birds with one stone : New therapies are needed to facilitate synergistic combinations that span distinct antitumor mechanisms. A small library of structurally relevant C,N‐cyclometalated ruthenium(II) complexes was synthesized and their pharmacologic efficacy was investigated. The cover art shows the structure of the complex Ru8 , which was demonstrated to have three antitumor functions, including potent cytotoxicity, antimetastasis and antivascular activity. The complex deserves further investigation as a promising drug candidate to combat metastatic cancer. More information can be found in the Full Paper by C. Chen, H. Wang, et al. on page 15170.