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Computational and Experimental Study of Turbo‐Organomagnesium Amide Reagents: Cubane Aggregates as Reactive Intermediates in Pummerer Coupling
Author(s) -
Planas Ferran,
Kohlhepp Stefanie V.,
Huang Genping,
Mendoza Abraham,
Himo Fahmi
Publication year - 2021
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202004164
Subject(s) - cubane , chemistry , amide , reagent , reactive intermediate , computational chemistry , yield (engineering) , reactivity (psychology) , molecule , organic chemistry , materials science , catalysis , metallurgy , medicine , alternative medicine , pathology
The dynamic equilibria of organomagnesium reagents are known to be very complex, and the relative reactivity of their components is poorly understood. Herein, a combination of DFT calculations and kinetic experiments is employed to investigate the detailed reaction mechanism of the Pummerer coupling between sulfoxides and turbo‐organomagnesium amides. Among the various aggregates studied, unprecedented heterometallic open cubane structures are demonstrated to yield favorable barriers through a concerted anion‐anion coupling/ S−O cleavage step. Beyond a structural curiosity, these results introduce open cubane organometallics as key reactive intermediates in turbo‐organomagnesium amide mixtures.