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Transition Metal‐Promoted Reactions in Aqueous Media and Biological Settings
Author(s) -
Destito Paolo,
Vidal Cristian,
López Fernando,
Mascareñas José L.
Publication year - 2021
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202003927
Subject(s) - transformative learning , aqueous medium , biocompatibility , nanotechnology , biocompatible material , biochemical engineering , chemistry , combinatorial chemistry , computer science , materials science , aqueous solution , engineering , sociology , organic chemistry , biomedical engineering , pedagogy
During the last decade, there has been a tremendous interest for developing non‐natural biocompatible transformations in biologically relevant media. Among the different encountered strategies, the use of transition metal complexes offers unique possibilities due to their high transformative power. However, translating the potential of metal catalysts to biological settings, including living cells or small‐animal models such as mice or zebrafish, poses numerous challenges associated to their biocompatibility, and their stability and reactivity in crowded aqueous environments. Herein, we describe the most relevant advances in this direction, with a particular emphasis on the systems’ structure, their mode of action and the mechanistic bases of each transformation. Thus, the key challenges from an organometallic perspective might be more easily identified.