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The Synthesis and Bioactivity of the Marine Macrolide Callyspongiolide
Author(s) -
Ko KwangYoon,
Wilson Zoe E.,
Brimble Margaret A.
Publication year - 2021
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202003898
Subject(s) - natural product , sponge , chemistry , macrolide antibiotics , stereochemistry , conjugated system , combinatorial chemistry , computational biology , biology , organic chemistry , botany , biochemistry , antibiotics , erythromycin , polymer
Abstract Callyspongiolide, a macrolide natural product with a conjugated diene‐ynic side chain, has garnered significant attention from the synthetic community since its isolation from a sea sponge in 2013. Herein, the approaches that have been applied to this bioactive natural product to date are reviewed. These synthetic endeavors have established the absolute stereochemistry of this molecule and allowed further investigation into its promising caspase‐independent bioactivity, while also contributing to the wider field of macrolide synthesis.