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Front Cover: SAR Studies of the Leupyrrins: Design and Total Synthesis of Highly Potent Simplified Leupylogs (Chem. Eur. J. 66/2020)
Author(s) -
Wosniok Paul R.,
Knopf Christopher,
Dreisigacker Sandra,
OrozcoRodriguez J. Manuel,
Hinkelmann Bettina,
Mueller Peter P.,
Brönstrup Mark,
Menche Dirk
Publication year - 2020
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202003844
Subject(s) - front cover , total synthesis , antifungal , cover (algebra) , chemistry , combinatorial chemistry , computational biology , stereochemistry , computer science , biology , engineering , microbiology and biotechnology , mechanical engineering
The design and total synthesis of dramatically simplified leupylogs is presented. They demonstrate similar highly potent antifungal activities as the natural leupyrrins, as depicted by a balanced IC 50 weighing scale. The origin of the secondary metabolites from the myxobacterium Sorangium cellulosum is illustrated by its fruiting bodies while the flask portrays the synthetic endeavors which have led to the discovery of leupylogs. More information can be found in the Communication by D. Menche et al. on page 15074.