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Synthesis of Fluoro‐, Monofluoromethyl‐, Difluoromethyl‐, and Trifluoromethyl‐Substituted Three‐Membered Rings
Author(s) -
Decaens Jonathan,
CouveBonnaire Samuel,
Charette André B.,
Poisson Thomas,
Jubault Philippe
Publication year - 2021
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202003822
Subject(s) - trifluoromethyl , ring (chemistry) , chemistry , stereochemistry , medicinal chemistry , organic chemistry , alkyl
This Minireview describes recent advances toward the synthesis of fluoro‐, monofluoromethyl‐, difluoromethyl‐, and trifluoromethyl‐substituted three‐membered rings such as cyclopropanes, aziridines, epoxides, episulfides, cyclopropenes, and 2 H ‐azirines. The main synthetic methodologies since 2016 for cyclopropanes and since 2010 for the other three‐membered rings are reported.