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The Synthesis of Warfarin Using a Reconfigurable‐Reactor Platform Integrated to a Multiple‐Variable Optimization Tool
Author(s) -
Kwak Jee Seong,
Bizarri Nour,
Sharif Sepideh,
Zhang Wenyao Peter,
Mallik Debasis,
Organ Michael G.
Publication year - 2020
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202003700
Subject(s) - computer science , variable (mathematics) , process engineering , engineering , mathematics , mathematical analysis
Optimization of the asymmetric synthesis of warfarin, an important anticoagulant, has been evaluated using a reconfigurable reaction platform capable of performing batch, continuous flow, and plug‐flow synthesis. Further, this platform has been integrated with a novel, multidimensional, multiple variable analysis tool that can evaluate multiple critical quality attributes (CQA), percent conversion and enantiomeric excess in this case, from a single injection that is repeatedly recycled in a closed loop of chromatography columns, a detector and a heart‐cut valve. Further, the new, integrated analysis system also facilitates validation of each QA, providing a high‐level of confidence in analytical measurements, which are obtained without operator intervention.