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Front Cover: Luminescent Bimetallic Ir III /Au I Peptide Bioconjugates as Potential Theranostic Agents (Chem. Eur. J. 53/2020)
Author(s) -
Luengo Andrés,
Marzo Isabel,
Reback Matthew,
Daubit Isabelle M.,
FernándezMoreira Vanesa,
MetzlerNolte Nils,
Gimeno M. Concepción
Publication year - 2020
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202003632
Subject(s) - bimetallic strip , front cover , chemistry , conjugate , peptide , linker , nanotechnology , combinatorial chemistry , metal , cover (algebra) , materials science , biochemistry , organic chemistry , computer science , mechanical engineering , mathematical analysis , mathematics , engineering , operating system
Iridium/gold bimetallic peptide bioconjugates are presented as a new source of theranostic agents. This work provides crucial insight into the factors that contribute to anti‐proliferative activity of generally toxic metal fragments in bioconjugates. While chemical tools and reactions exist to link metal fragments to selected sites in peptides almost at will, the exact choice of linker and the resulting coordination environment crucially contribute to the overall activity of the conjugate. More information can be found in the Full Paper by V. Fernández‐Moreira, N. Metzler‐Nolte, M. C. Gimeno, et al. on page 12158.