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Cover Feature: Five‐Step Enantioselective Synthesis of Islatravir via Asymmetric Ketone Alkynylation and an Ozonolysis Cascade (Chem. Eur. J. 62/2020)
Author(s) -
Patel Niki R.,
Huffman Mark A.,
Wang Xiao,
Ding Bangwei,
McLaughlin Mark,
Newman Justin A.,
Andreani Teresa,
Maloney Kevin M.,
Johnson Heather C.,
Whittaker Aaron M.
Publication year - 2020
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202003600
Subject(s) - enantioselective synthesis , alkynylation , cascade , ozonolysis , chemistry , ketone , catalysis , cascade reaction , stereochemistry , cover (algebra) , combinatorial chemistry , organic chemistry , mechanical engineering , chromatography , engineering
A ball‐and‐stick Houk‐style view of islatravir , the target of the total synthesis described in this work, is depicted in the cover image. Islatravir is on top of a “caged” Human Immunodeficiency Virus to indicate that the molecule is an HIV translocation‐transcriptase inhibitor. In the center of the picture is a circle showing the three key catalytic steps of the synthesis; a biocatalytic cascade, an enantioselective alkynylation, and an ozonolysis deprotection cascade. More information can be found in the Full Paper by H. C. Johnson, A. M. Whittaker, et al. on page 14118.