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Cover Feature: Conformational Sensing by a Mammalian Olfactory Receptor (Chem. Eur. J. 50/2020)
Author(s) -
Liu Min Ting,
Na Mihwa,
Li Yadi,
Biscoe Mark R.,
Ryan Kevin
Publication year - 2020
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202003590
Subject(s) - agonist , olfactory receptor , chemistry , olfactory bulb , biophysics , calcium imaging , partial agonist , receptor , stereochemistry , neuroscience , psychology , biochemistry , calcium , biology , organic chemistry , central nervous system
Conformational Sensing : Olfactory receptor model superimposed on a stylized calcium imaging heatmap background. New evidence supports the hypothesis that different odorant conformations can lead to different receptor outputs, with the ensemble of conformations producing a composite response. The depicted octanal conformations were tested in Olfr2‐expressing neurons by use of conformationally restricted analogs. From top to bottom, conformations corresponding to: antagonist, partial agonist, full agonist. More information can be found in the Full Paper by K. Ryan et al. on page 11462.