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Cover Feature: Single Peptide Backbone Surrogate Mutations to Regulate Angiotensin GPCR Subtype Selectivity (Chem. Eur. J. 47/2020)
Author(s) -
Vrettos Eirinaios I.,
Valverde Ibai E.,
Mascarin Alba,
Pallier Patrick N.,
Cerofolini Linda,
Fragai Marco,
Parigi Giacomo,
Hirmiz Baydaa,
Bekas Nick,
Grob Nathalie M.,
Stylos Evgenios Κ.,
Shaye Hamidreza,
Del Borgo Mark,
Aguilar MarieIsabel,
Magnani Francesca,
Syed Nelofer,
Crook Timothy,
Waqif Emal,
Ghazaly Essam,
Cherezov Vadim,
Widdop Robert E.,
Luchinat Claudio,
MichaelTitus Adina T.,
Mindt Thomas L.,
Tzakos Andreas G.
Publication year - 2020
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202003569
Subject(s) - neurite , angiotensin ii , peptide , chemistry , selectivity , dapi , angiotensin receptor , renin–angiotensin system , phenotype , microbiology and biotechnology , biochemistry , biology , receptor , in vitro , gene , endocrinology , apoptosis , blood pressure , catalysis
Single peptide backbone surrogate 1,2,3‐triazole mutations can regulate angiotensin GPCR subtype selectivity. [Y]6‐Angiotensin II analogs with amide bonds replaced by 1,4‐disubstituted isosteres illustrated enhanced AT2R/AT1R subtype selectivity and enhanced neurite growth in embryonic mouse cortical cells (E15). Neurite outgrowth (red color) was visualized using an anti‐MAP2 antibody. Nuclei, in blue, were stained with DAPI. Photos were taken using an epifluorescence microscope at ×20. More information can be found in the Communication by T. L. Mindt, A. G. Tzakos, et al. on page 10690.