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Natural Products Originated from the Oxidative Coupling of Tyrosine and Tryptophan: Biosynthesis and Bioinspired Synthesis
Author(s) -
Tang Shanyu,
Vincent Guillaume
Publication year - 2021
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202003459
Subject(s) - biosynthesis , tyrosine , tryptophan , oxidative phosphorylation , oxidative coupling of methane , chemistry , coupling (piping) , biochemistry , amino acid , materials science , gene , catalysis , metallurgy
The oxidative coupling of tyrosine and tryptophan units is a pivotal step in the total synthesis of some peptide‐derived marine and terrestrial natural products, such as the diazonamides, azonazine and tryptorubin A. This Minireview details the biosynthesis and bioinspired synthesis of natural products with such structures. A special focus is put on the challenges of the synthesis of these natural products and the innovative solutions adopted by synthetic chemists.