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Lewis Acid Promoted Dearomatization of Naphthols
Author(s) -
Kulish Kirill,
Boldrini Cosimo,
Castiñeira Reis Marta,
Pérez Juana M.,
Harutyunyan Syuzanna R.
Publication year - 2020
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202003392
Subject(s) - lewis acids and bases , chemistry , catalysis , ring (chemistry) , lewis acid catalysis , organic chemistry , copper , surface modification , combinatorial chemistry
Two‐step dearomative functionalization of naphthols promoted by Lewis acids and copper(I) catalysis was developed. Initially, Lewis acid complexation inverted the electronic properties of the ring and established an equilibrium with the dearomatized counterpart. Subsequent trapping of the dearomatized intermediate with organometallics as well as organophosphines was demonstrated and provided the corresponding dearomatized products.