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Cover Feature: Highly Chemoselective Esterification from O ‐Aminoallylation of Carboxylic Acids: Metal‐ and Reagent‐Free Hydrocarboxylation of Allenamides (Chem. Eur. J. 61/2020)
Author(s) -
Pradhan Tapas R.,
Lee Hae Eun,
GonzalezMontiel Gisela A.,
Cheong Paul HaYeon,
Park Jin Kyoon
Publication year - 2020
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202003338
Subject(s) - chemoselectivity , reagent , chemistry , protonation , carboxylic acid , inert gas , combinatorial chemistry , organic chemistry , catalysis , ion
Fishing carboxylic acids with allenamides as the bait are depicted for demonstrating a mild transformation employing allenamides as amino allyl surrogates for the esterification naturally abundant carboxylic acids feedstock; the cover shows some fish reaching the bait, hence representing the chemoselectivity of the developed protocol. The transparent nature of the sea water with air bubbles clarified that the present O‐aminoallylation reaction does not require any external reagent and inert atmosphere. A DFT‐study revealed that the reaction occurs via a protonation event as shown at the top of the picture. More information can be found in the Full Paper by P. H.‐Y. Cheong, J. K. Park, et al. on page 13826.