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Alternating Magnetic Field Controlled Targeted Drug Delivery Based on Graphene Oxide‐Grafted Nanosupramolecules
Author(s) -
Zhang Bing,
Yu Qilin,
Liu Yu
Publication year - 2020
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202003328
Subject(s) - nanocarriers , graphene , drug delivery , hyaluronic acid , drug , doxorubicin , peptide , nanotechnology , materials science , biophysics , oxide , targeted drug delivery , supramolecular chemistry , cyclodextrin , controlled release , magnetic nanoparticles , nanomedicine , nanoparticle , chemistry , pharmacology , biochemistry , organic chemistry , medicine , chemotherapy , biology , surgery , crystal structure , anatomy
Graphene oxide (GO)‐grafted nanosupramolecules have recently emerged as neoteric nano drug carriers in the therapy of refractory diseases. Herein, a multicomponent nanosupramolecular drug carrier based on a targeted peptide and magnetic GO is reported, the drug‐release behavior of which can be regulated by an alternating magnetic field (AMF). This multicomponent nanosupramolecular carrier is composed of β‐cyclodextrin (β‐CD)/nickel nanoparticle‐modified graphene oxide (GONiCD) and mitochondrial ion‐targeting peptide (MitP)‐grafted hyaluronic acid (HAMitP). Owing to the host–guest interaction between β‐cyclodextrin and the cyclohexyl groups on MitP, GONiCD and HAMitP could form supramolecular assemblies during the doxorubicin (Dox) loading process, which not only remarkably enhances the drug‐loading capacity, but also improves the drug‐release efficiency under AMF stimulus. During co‐incubation with tumor cells, the Dox‐loaded assemblies could strongly target the tumor mitochondria and damage both the mitochondria and the nuclei, owing to Dox release from the assemblies induced by AMF. This study sheds light on the exploration of peptide caps for controlled drug loading/release of supramolecular nanocarriers for efficient drug delivery and anticancer therapy.