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Cover Feature: Polypyridyl‐Based Copper Phenanthrene Complexes: Combining Stability with Enhanced DNA Recognition (Chem. Eur. J. 3/2021)
Author(s) -
Fantoni Nicoló Zuin,
Molphy Zara,
O'Carroll Sinéad,
Menounou Georgia,
Mitrikas George,
Krokidis Marios G.,
Chatgilialoglu Chryssostomos,
Colleran John,
Banasiak Anna,
Clynes Martin,
Roche Sandra,
Kelly Suainibhe,
McKee Vickie,
Kellett Andrew
Publication year - 2021
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202003314
Subject(s) - chemistry , intercalation (chemistry) , dna , ligand (biochemistry) , copper , phenanthrene , helix (gastropod) , combinatorial chemistry , crystallography , stereochemistry , crystal structure , receptor , biochemistry , inorganic chemistry , organic chemistry , biology , ecology , snail
A new class of DNA intercalating metallodrug is reported . These agents contain a polypyridyl caging ligand called DPA which is bound to a copper ion ligated to a phenanthrene (Phen) DNA intercalator. The lead agent is Cu‐DPA‐DPPZ and it can recognize the minor groove of G–C rich DNA sequences and displays promising activity against several pancreatic cancer cell lines. The graphic shows the Cu‐DPA‐DPPZ complex intercalating the minor groove of a G–C DNA sequence taken from the protein data bank (2ANA). The modeling was completed using PyMOL together with the X‐ray crystal structure of the complex. More information can be found in the Full Paper by A. Kellett et al. on page 971.