Premium
Cover Feature: (Iso)Quinoline–Artemisinin Hybrids Prepared through Click Chemistry: Highly Potent Agents against Viruses (Chem. Eur. J. 52/2020)
Author(s) -
Çapcı Aysun,
Lorion Mélanie M.,
Mai Christina,
Hahn Friedrich,
Hodek Jan,
Wangen Christina,
Weber Jan,
Marschall Manfred,
Ackermann Lutz,
Tsogoeva Svetlana B.
Publication year - 2020
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202003234
Subject(s) - isoquinoline , artemisinin , quinoline , combinatorial chemistry , chemistry , ganciclovir , computational biology , cover (algebra) , virology , stereochemistry , biology , virus , organic chemistry , engineering , malaria , plasmodium falciparum , immunology , mechanical engineering , human cytomegalovirus
Structural hybridization of bioactive heterocycles is a promising tool to develop new efficient therapeutics for the treatment of various diseases including viral infections. The merging of two differently acting heterocycles—artemisinin and isoquinoline—in one hybrid molecule results in the discovery of a new and potent antiviral agent, which exceeds parent compounds in anti‐HCMV and anti‐HBV activities and is even able to outperform the clinically used drug ganciclovir. More information can be found in the Full Paper by L. Ackermann, S. B. Tsogoeva, et al. on page 12019.