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A Serendipitous One‐Pot Cyanation/Hydrolysis/Enamide Formation: Direct Access to 3‐Methyleneisoindolin‐1‐ones
Author(s) -
Banik Trisha,
Kaliappan Krishna P.
Publication year - 2021
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202003209
Subject(s) - scope (computer science) , cyanation , reagent , combinatorial chemistry , substrate (aquarium) , chemistry , hydrolysis , transformation (genetics) , biochemical engineering , nanotechnology , computer science , organic chemistry , biochemistry , materials science , engineering , catalysis , biology , ecology , programming language , gene
A direct, one‐pot conversion of 2’‐haloacetophenones to 3‐methyleneisoindolin‐1‐one scaffolds using CuCN as the sole reagent without the need for moisture‐free or anaerobic conditions is reported. This serendipitously discovered transformation with a broad substrate scope provides a significantly different route towards these important scaffolds. The scope of the method has also been further extended towards the synthesis of three special scaffolds, which are analogous to various bio‐active drugs.