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Construction of Smart Stimuli‐Responsive DNA Nanostructures for Biomedical Applications
Author(s) -
Wang Huimin,
Luo Dan,
Wang Hong,
Wang Fuan,
Liu Xiaoqing
Publication year - 2021
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202003145
Subject(s) - nanotechnology , nanomedicine , drug delivery , smart material , nanostructure , dna nanotechnology , materials science , biocompatibility , biosensor , computer science , dna , chemistry , nanoparticle , biochemistry , metallurgy
DNA nanostructures have recently attracted increasing interest in biological and biomedical applications by virtue of their unique properties, such as structural programmability, multi‐functionality, stimuli‐responsive behaviors, and excellent biocompatibility. In particular, the intelligent responsiveness of smart DNA nanostructures to specific stimuli has facilitated their extensive development in the field of high‐performance biosensing and controllable drug delivery. This minireview begins with different self‐assembly strategies for the construction of various DNA nanostructures, followed by the introduction of a variety of stimuli‐responsive functional DNA nanostructures for assembling metastable soft materials and for facilitating amplified biosensing. The recent achievements of smart DNA nanostructures for controllable drug delivery are highlighted. Finally, the current challenges and possible developments of this promising research are discussed in the fields of intelligent nanomedicine.