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Statistical Analysis of Glycosylation Reactions
Author(s) -
Chang ChunWei,
Lin MeiHuei,
Wang ChengChung
Publication year - 2021
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202003105
Subject(s) - stereoselectivity , glycosylation , chemistry , outcome (game theory) , combinatorial chemistry , computational chemistry , organic chemistry , biochemistry , catalysis , mathematics , mathematical economics
Chemical synthesis is one of the practical approaches to access carbohydrate‐based natural products and their derivatives with high quality and in a large quantity. However, stereoselectivity during the glycosylation reaction is the main challenge because the reaction can generate both α‐ and β‐glycosides. The main focus of the present article is the concept of recent mechanistic studies that have applied statistical analysis and quantitation for defining stereoselective changes during the reaction process. Based on experimental evidence, a detailed discussion associated with the mechanism and degree of influence affecting the stereoselective outcome of glycosylation is included.