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Cover Feature: On‐Chip Neo‐Glycopeptide Synthesis for Multivalent Glycan Presentation (Chem. Eur. J. 44/2020)
Author(s) -
Mende Marco,
Tsouka Alexandra,
Heidepriem Jasmin,
Paris Grigori,
Mattes Daniela S.,
Eickelmann Stephan,
Bordoni Vittorio,
Wawrzinek Robert,
Fuchsberger Felix F.,
Seeberger Peter H.,
Rademacher Christoph,
Delbianco Martina,
Mallagaray Alvaro,
Loeffler Felix F.
Publication year - 2020
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202003015
Subject(s) - glycan , glycopeptide , click chemistry , chemistry , feature (linguistics) , nanotechnology , combinatorial chemistry , materials science , glycoprotein , biochemistry , antibiotics , linguistics , philosophy
Laser‐based patterning technology allows for flexible and rapid on‐surface microarray synthesis of peptide scaffolds. In combination with click chemistry, a multitude of neo‐glycopeptides can be directly produced on functionalized glass slides in the microarray format. Density and spatial distribution of carbohydrates can be easily tuned to obtain well‐defined glycan structures for multivalent display. Lectins reveal strong spacing‐, density‐, and ligand‐dependent binding to these multivalent structures. More information can be found in the Full Paper by F. F. Loeffler et al. on page 9954.