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Esterase‐Activatable Synthetic M + /Cl − Channel Induces Apoptosis and Disrupts Autophagy in Cancer Cells
Author(s) -
Malla Javid Ahmad,
Sharma Virender Kumar,
Lahiri Mayurika,
Talukdar Pinaki
Publication year - 2020
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202002964
Subject(s) - autophagy , apoptosis , cancer cell , chemistry , lipid bilayer , microbiology and biotechnology , membrane , biophysics , cancer , biochemistry , biology , genetics
The formation of a supramolecular synthetic M + /Cl − channel in the membrane phospholipid bilayer has been reported upon activation of a methyl pivalate‐linked N 1 , N 3 ‐dialkyl‐2‐hydroxyisophthalamide by esterases. The channel formation induces apoptosis in cancer cells via the intrinsic pathway. Interestingly, the supramolecular channel was also shown to disrupt autophagy in cancer cells by causing alkalization of lysosomes – a feature that has been confirmed at the cellular and protein level.