Premium
UV‐Induced 1,3,4‐Oxadiazole Formation from 5‐Substituted Tetrazoles and Carboxylic Acids in Flow
Author(s) -
Green Luke,
Livingstone Keith,
Bertrand Sophie,
Peace Simon,
Jamieson Craig
Publication year - 2020
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202002896
Subject(s) - substrate (aquarium) , scope (computer science) , oxadiazole , chemistry , combinatorial chemistry , carboxylic acid , organic chemistry , computer science , programming language , oceanography , geology
A range of 1,3,4‐oxadiazoles have been synthesized using a UV‐B activated flow approach starting from carboxylic acids and 5‐substituted tetrazoles. The application of UV light represents an attractive alternative to the traditional thermolytic approach and has demonstrated comparable efficiency and versatility, with a diverse substrate scope, including the incorporation of highly substituted amino acids.