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Copper‐Catalyzed Oxidative Cross‐Coupling of Electron‐Deficient Polyfluorophenylboronate Esters with Terminal Alkynes
Author(s) -
Liu Zhiqiang,
Budiman Yudha P.,
Tian YaMing,
Friedrich Alexandra,
Huang Mingming,
Westcott Stephen A.,
Radius Udo,
Marder Todd B.
Publication year - 2020
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202002888
Subject(s) - sonogashira coupling , catalysis , oxidative phosphorylation , substrate (aquarium) , oxidative coupling of methane , terminal (telecommunication) , chemistry , coupling (piping) , combinatorial chemistry , functional group , copper , electron , coupling reaction , photochemistry , organic chemistry , palladium , materials science , physics , computer science , biochemistry , telecommunications , polymer , metallurgy , oceanography , quantum mechanics , geology
We report herein a mild procedure for the copper‐catalyzed oxidative cross‐coupling of electron‐deficient polyfluorophenylboronate esters with terminal alkynes. This method displays good functional group tolerance and broad substrate scope, generating cross‐coupled alkynyl(fluoro)arene products in moderate to excellent yields. Thus, it represents a simple alternative to the conventional Sonogashira reaction.