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Cannabidiol Discovery and Synthesis—a Target‐Oriented Analysis in Drug Production Processes
Author(s) -
Aguillón Anderson R.,
Leão Raquel A. C.,
Miranda Leandro S. M.,
Souza Rodrigo O. M. A.
Publication year - 2021
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202002887
Subject(s) - cannabidiol , cannabinoid , drug discovery , cannabis , microbiology and biotechnology , chemistry , medicine , biology , psychiatry , biochemistry , receptor
The current state of evidence and recommendations for cannabidiol (CBD) and its health effects change the legal landscape and aim to destigmatize its phytotherapeutic research. Recently, some countries have included CBD as an antiepileptic product for compassionate use in children with refractory epilepsy. The growing demand for CBD has led to the need for high‐purity cannabinoids on the emerging market. The discovery and development of approaches toward CBD synthesis have arisen from the successful extraction of Cannabis plants for cannabinoid fermentation in brewer's yeast. To understand different contributions to the design and enhancement of the synthesis of CBD and its key intermediates, a detailed analysis of the history behind cannabinoid compounds and their optimization is provided herein.