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Stereoselective Remote Functionalization via Palladium‐Catalyzed Redox‐Relay Heck Methodologies
Author(s) -
Bonfield Holly E.,
Valette Damien,
Lindsay David M.,
Reid Marc
Publication year - 2021
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202002849
Subject(s) - stereocenter , scope (computer science) , combinatorial chemistry , palladium , stereoselectivity , drug discovery , chemical space , computer science , nanotechnology , biochemical engineering , chemistry , enantioselective synthesis , catalysis , materials science , engineering , organic chemistry , biochemistry , programming language
Exploration of novel, three‐dimensional chemical space is of growing interest in the drug discovery community and with this comes the challenge for synthetic chemists to devise new stereoselective methods to introduce chirality in a rapid and efficient manner. This Minireview provides a timely summary of the development of palladium‐catalyzed asymmetric redox‐relay Heck‐type processes. These reactions represent an important class of transformation for the selective introduction of remote stereocenters, and have risen to prominence over the past decade. Within this Minireview, the vast scope of these transformations will be showcased, alongside applications to pharmaceutically relevant chiral building blocks and drug substances. To complement this overview, a mechanistic summary and discussion of the current limitations of the transformation are presented, followed by an outlook on future areas of investigation.