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Nickel‐Catalyzed Amination of (Hetero)aryl Halides Facilitated by a Catalytic Pyridinium Additive
Author(s) -
Han Dongyang,
Li Sasa,
Xia Siqi,
Su Mincong,
Jin Jian
Publication year - 2020
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202002800
Subject(s) - amination , pyridinium , aryl , catalysis , halide , chemistry , alkyl , yield (engineering) , nickel , imine , organic chemistry , cyanuric chloride , combinatorial chemistry , salt (chemistry) , materials science , metallurgy
An efficient and operationally simple Ni‐catalyzed amination protocol has been developed. This methodology features a simple Ni II salt, an organic base and catalytic amounts of both a pyridinium additive and Zn metal. A diverse number of (hetero)aryl halides were coupled successfully with primary and secondary alkyl amines, and anilines in good to excellent yields. Similarly, benzophenone imine gave the corresponding N ‐arylation product in an excellent yield.
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