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Catalytic Transfer Hydrogenation of Arenes and Heteroarenes
Author(s) -
Gelis Coralie,
Heusler Arne,
Nairoukh Zackaria,
Glorius Frank
Publication year - 2020
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202002777
Subject(s) - catalysis , transfer hydrogenation , benzene , chemistry , context (archaeology) , molecule , benzene derivatives , hydrogen , hydrogen molecule , organic chemistry , catalytic hydrogenation , combinatorial chemistry , photochemistry , chemical synthesis , paleontology , biochemistry , ruthenium , in vitro , biology
Transfer hydrogenation reactions are of great interest to reduce diverse molecules under mild reaction conditions. To date, this type of reaction has only been successfully applied to alkenes, alkynes and polarized unsaturated compounds such as ketones, imines, pyridines, etc. The reduction of benzene derivatives by transfer hydrogenation has never been described, which is likely due to the high energy barrier required to dearomatize these compounds. In this context, we have developed a catalytic transfer hydrogenation reaction for the reduction of benzene derivatives and heteroarenes to form complex 3‐dimensional scaffolds bearing various functional groups at room temperature without needing compressed hydrogen gas.