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Supramolecular Assembly of TPE‐Based Glycoclusters with Dicyanomethylene‐4 H ‐pyran (DM) Fluorescent Probes Improve Their Properties for Peroxynitrite Sensing and Cell Imaging
Author(s) -
Dong Lei,
Fu Mengqi,
Liu Lifang,
Han HaiHao,
Zang Yi,
Chen GuoRong,
Li Jia,
He XiaoPeng,
Vidal Sébastien
Publication year - 2020
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202002772
Subject(s) - peroxynitrite , fluorescence , tetraphenylethylene , supramolecular chemistry , chemistry , quenching (fluorescence) , biophysics , nanotechnology , photochemistry , combinatorial chemistry , materials science , biochemistry , molecule , aggregation induced emission , organic chemistry , biology , physics , quantum mechanics , enzyme , superoxide
Two red‐emitting dicyanomethylene‐4 H ‐pyran (DM) based fluorescent probes were designed and used for peroxynitrite (ONOO − ) detection. Nevertheless, the aggregation‐caused quenching effect diminished the fluorescence and restricted their further applications. To overcome this problem, tetraphenylethylene (TPE) based glycoclusters were used to self‐assemble with these DM probes to obtain supramolecular water‐soluble glyco‐dots. This self‐assembly strategy enhanced the fluorescence intensity, leading to an enhanced selectivity and activity of the resulting glyco‐dot comparing to DM probes alone in PBS buffer. The glyco‐dots also exhibited better results during fluorescence sensing of intracellular ONOO − than the probes alone, thereby offering scope for the development of other similar supramolecular glyco‐systems for chemical biological studies.