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Front Cover: One Way Traffic: Base‐to‐Backbone Hole Transfer in Nucleoside Phosphorodithioate (Chem. Eur. J. 43/2020)
Author(s) -
Kaczmarek Renata,
Ward Samuel,
Debnath Dipra,
Jacobs Taisiya,
Stark Alexander D.,
Korczyński Dariusz,
Kumar Anil,
Sevilla Michael D.,
Denisov Sergey A.,
Shcherbakov Viacheslav,
Pernot Pascal,
Mostafavi Mehran,
Dembinski Roman,
Adhikary Amitava
Publication year - 2020
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202002714
Subject(s) - cover (algebra) , guanine , base pair , unpaired electron , base (topology) , dna , electron transfer , chemistry , nucleoside , nucleotide , molecule , stereochemistry , photochemistry , organic chemistry , biochemistry , engineering , mathematics , mechanical engineering , mathematical analysis , gene
The direction of hole transfer (unpaired spin) in the DNA‐component, occurring between base and modified phosphate, is depicted in the cover artwork. This process critically determines the DNA‐backbone damage. In one‐electron oxidized phosphorodithioate nucleotide, the hole is initially localized on guanine base as a cation radical (Gua .+ ). Next, via base‐to‐backbone hole transfer, the hole appears on phosphorodithioate as dithiyl radical. Cover art designed by Ariela Kaspi‐Kaneti, with contribution from Aditya Paul. More information can be found in the Full Paper by R. Dembinski, A. Adhikary, et al. on page 9495.