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Parahydrogen‐Induced Polarization of Diethyl Ether Anesthetic
Author(s) -
Ariyasingha Nuwandi M.,
Joalland Baptiste,
Younes Hassan R.,
Salnikov Oleg G.,
Chukanov Nikita V.,
Kovtunov Kirill V.,
Kovtunova Larisa M.,
Bukhtiyarov Valerii I.,
Koptyug Igor V.,
Gelovani Juri G.,
Chekmenev Eduard Y.
Publication year - 2020
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202002528
Subject(s) - spin isomers of hydrogen , hyperpolarization (physics) , diethyl ether , chemistry , proton , nuclear magnetic resonance , polarization (electrochemistry) , nuclear magnetic resonance spectroscopy , hydrogen , physics , organic chemistry , chromatography , quantum mechanics
The growing interest in magnetic resonance imaging (MRI) for assessing regional lung function relies on the use of nuclear spin hyperpolarized gas as a contrast agent. The long gas‐phase lifetimes of hyperpolarized 129 Xe make this inhalable contrast agent acceptable for clinical research today despite limitations such as high cost, low throughput of production and challenges of 129 Xe imaging on clinical MRI scanners, which are normally equipped with proton detection only. We report on low‐cost and high‐throughput preparation of proton‐hyperpolarized diethyl ether, which can be potentially employed for pulmonary imaging with a nontoxic, simple, and sensitive overall strategy using proton detection commonly available on all clinical MRI scanners. Diethyl ether is hyperpolarized by pairwise parahydrogen addition to vinyl ethyl ether and characterized by 1 H NMR spectroscopy. Proton polarization levels exceeding 8 % are achieved at near complete chemical conversion within seconds, causing the activation of radio amplification by stimulated emission radiation (RASER) throughout detection. Although gas‐phase T 1 relaxation of hyperpolarized diethyl ether (at partial pressure of 0.5 bar) is very efficient, with T 1 of ca. 1.2 second, we demonstrate that, at low magnetic fields, the use of long‐lived singlet states created via pairwise parahydrogen addition extends the relaxation decay by approximately threefold, paving the way to bioimaging applications and beyond.