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Germacrene A–A Central Intermediate in Sesquiterpene Biosynthesis
Author(s) -
Xu Houchao,
Dickschat Jeroen S.
Publication year - 2020
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202002163
Subject(s) - germacrene , sesquiterpene , biosynthesis , stereochemistry , bicyclic molecule , chemistry , absolute configuration , organic chemistry , enzyme
This review summarises known sesquiterpenes whose biosyntheses proceed through the intermediate germacrene A. First, the occurrence and biosynthesis of germacrene A in Nature and its peculiar chemistry will be highlighted, followed by a discussion of 6–6 and 5–7 bicyclic compounds and their more complex derivatives. For each compound the absolute configuration, if it is known, and the reasoning for its assignment is presented.