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Highlights on the Binding of Cobalta‐Bis‐(Dicarbollide) with Glucose Units
Author(s) -
Merhi Tania,
Jonchère Alban,
Girard Luc,
Diat Olivier,
Nuez Miquel,
Viñas Clara,
Bauduin Pierre
Publication year - 2020
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202002123
Subject(s) - micelle , chemistry , moiety , critical micelle concentration , monomer , pulmonary surfactant , combinatorial chemistry , biophysics , stereochemistry , organic chemistry , biochemistry , aqueous solution , polymer , biology
Metalla‐bis‐dicarbollides, such as the cobalta‐bis‐dicarbollide (COSAN) anion [Co(C 2 B 9 H 11 ) 2 ] − , have attracted much attention in biology but a deep understanding of their interactions with cell components is still missing. For this purpose, we studied the interactions of COSAN with the glucose moiety, which is ubiquitous at biological interfaces. Octyl‐glucopyranoside surfactant (C8G1) was chosen as a model as it self‐assembles in water and creates a hydrated glucose‐covered interface. At low COSAN content and below the critical micellar concentration (CMC) of C8G1, COSAN binds to C8G1 monomers through the hydrophobic effect. Above the CMC of C8G1, COSAN adsorbs onto C8G1 micelles through the superchaotropic effect. At high COSAN concentrations, COSAN disrupts C8G1 micelles and the assemblies become similar to COSAN micelles but with a small amount of solubilized C8G1. Therefore, COSAN binds in a versatile way to C8G1 through either the hydrophobic or superchaotropic effect depending on their relative concentrations.