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Brønsted Acid‐Catalysed Dehydrative Substitution Reactions of Alcohols
Author(s) -
EstopiñáDurán Susana,
Taylor James E.
Publication year - 2021
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202002106
Subject(s) - brønsted–lowry acid–base theory , electrophilic substitution , substitution (logic) , electrophile , chemistry , substitution reaction , catalysis , reactivity (psychology) , organic chemistry , combinatorial chemistry , electrophilic aromatic substitution , computer science , medicine , alternative medicine , pathology , programming language
Abstract The direct, catalytic dehydrative substitution of alcohols is a challenging, yet highly desirable process in the development of more sustainable approaches to organic chemistry. This review outlines recent advances in Brønsted acid‐catalysed dehydrative substitution reactions for C−C, C−O, C−N and C−S bond formation. The wide range of processes that are now accessible using simple alcohols as the formal electrophile are highlighted, while current limitations and therefore possible future directions for research are also discussed.