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Hexanoate‐Cucurbit[7]uril: Highly Soluble with Controlled Release Ability
Author(s) -
Chen Hao,
Zhang Jin,
Yu Qun,
Chen Yanru,
Tan Yebang
Publication year - 2020
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202001959
Subject(s) - solubility , drug delivery , chemistry , drug , ethyl hexanoate , aqueous solution , stereochemistry , nanotechnology , combinatorial chemistry , materials science , biochemistry , pharmacology , organic chemistry , biology , ethyl acetate
Current drug delivery systems gain more functions with increased complexity. With the idea of less is more, we synthesized hexanoate‐cucurbit[7]uril (CB[7]C 5 COONa) with multiple promising features for drug delivery. The hexanoate group integrates multiple functions. It endows CB[7]C 5 COONa extremely high solubility of over 600 mg mL −1 and well‐defined pH‐controlled release ability without sacrificing on the high binding affinity of CB[7] cavity. Based on the pH‐controlled release ability, CB[7]C 5 COONa can be used for controlling the bioactivity of drug molecules. We anticipate that the strategy of function integration would be useful for the design of simple yet powerful drug delivery systems.