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Synthesis of Diverse Aromatic Ketones through C−F Cleavage of Trifluoromethyl Group
Author(s) -
Ikeda Mai,
Matsuzawa Tsubasa,
Morita Takamoto,
Hosoya Takamitsu,
Yoshida Suguru
Publication year - 2020
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202001816
Subject(s) - trifluoromethyl , aryne , ketone , chemistry , cleavage (geology) , group (periodic table) , functional group , aromaticity , stereochemistry , organic chemistry , medicinal chemistry , molecule , materials science , alkyl , fracture (geology) , composite material , polymer
An efficient synthetic method of aromatic ketones through C−F cleavage of trifluoromethyl group is disclosed. The high functional group tolerance of the transformation and the remarkable stability of trifluoromethyl group in various reactions enabled multi‐substituted aromatic ketone synthesis in an efficient route involving useful transformations such as ortho ‐lithiation, aryne chemistry, and cross‐couplings.