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Continuous Electrochemical Synthesis of Iso‐Coumarin Derivatives from o ‐(1‐Alkynyl) Benzoates under Metal‐ and Oxidant‐Free
Author(s) -
Lin Xinxin,
Fang Zheng,
Zeng Cuilian,
Zhu Chenlong,
Pang Xinyan,
Liu Chengkou,
He Wei,
Duan Jindian,
Qin Ning,
Guo Kai
Publication year - 2020
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202001766
Subject(s) - electrosynthesis , microreactor , chemistry , catalysis , electrochemistry , electrocatalyst , benzoates , combinatorial chemistry , coumarin , electrolysis , radical , organic synthesis , metal , organic chemistry , electrode , electrolyte
A non‐oxidant and metal‐free strategy for synthesizing iso‐coumarin by using a continuous electrochemical microreactor to initiate an oxidative cyclization reaction of o ‐(1‐alkynyl) benzoate and radicals. This efficient and clean continuous electrosynthesis method not only avoids the complicated gas protection operation and production of by‐products in the batch processes, but also help to overcome the difficulty that batch metal catalysis and electrocatalysis are difficult to scale up, and has the potential for pilot‐scale experiment.