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Ultrasound‐Facilitated Direct meta ‐C−H Functionalization of Arenes: A Time‐Economical Strategy under Ambient Temperature with Improved Yield and Selectivity
Author(s) -
Jayarajan Ramasamy,
Chandrashekar Hediyala B.,
Dalvi Aishwarya K.,
Maiti Debabrata
Publication year - 2020
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202001757
Subject(s) - surface modification , selectivity , alkylation , yield (engineering) , chemistry , combinatorial chemistry , catalysis , sonochemistry , palladium , organic chemistry , materials science , metallurgy
The horizon of ultrasound‐assistance has been expanded to palladium‐catalyzed distal C−H functionalization of arenes. Compared to thermal conditions, operationally simple ultrasound mediated distal C−H functionalization occurred with a shorter reaction time and enhanced reactivity of reactants to give superior yields with improved selectivity both in terms of meta :others and mono:di. A wide variety of meta ‐functionalizations such as olefination, alkylation, acetoxylation, allylation and cyanation were successfully carried out under ambient temperature.