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Designed Boron‐Rich Polymeric Nanoparticles Based on Nano‐ion Pairing for Boron Delivery
Author(s) -
Li Jianwei,
Janoušková Olga,
FernandezAlvarez Roberto,
Mesíková Soňa,
Tošner Zdeněk,
Kereïche Sami,
Uchman Mariusz,
Matějíček Pavel
Publication year - 2020
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202001699
Subject(s) - boron , nanoparticle , cationic polymerization , materials science , copolymer , chemical engineering , polymer , ion , nanotechnology , nano , salt (chemistry) , polymer chemistry , chemistry , organic chemistry , composite material , engineering
Boron‐rich particles with the boron fraction ca.10–20 wt % of controllable shape and size that can be easily prepared via simple ion co‐assembly are promising material for tumor treatment by boron neutron capture therapy. Electroneutral, dynamic core‐shell polymeric nanoparticles were prepared by co‐assembly of cationic PEO‐ block ‐PGEA diblock copolymer with sodium closo ‐dodecaborate, Na 2 [B 12 H 12 ]. This is the first example of polymer nanoparticles based on [B 12 H 12 ] 2− nano‐ion pairing. The high [B 12 H 12 ] 2− loading is proven by calorimetry at physiological salt concentration. As a result of rational design, rod‐, worm‐ and sphere‐like particles were produced and further tested using human glioblastoma and cervical carcinoma cell lines. Rod‐like particles yielded the highest internalization capability in all tested cell lines.