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Friedel–Crafts Type Methylation with Dimethylhalonium Salts
Author(s) -
Hämmerling Sebastian,
Voßnacker Patrick,
Steinhauer Simon,
Beckers Helmut,
Riedel Sebastian
Publication year - 2020
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202001457
Subject(s) - friedel–crafts reaction , methylation , type (biology) , chemistry , organic chemistry , biology , biochemistry , paleontology , gene , catalysis
The dimethylchloronium salt [Me 2 Cl][Al(OTeF 5 ) 4 ] is used to methylate electron‐deficient aromatic systems in Friedel–Crafts type reactions as shown by the synthesis of N ‐methylated cations, such as [MeNC 5 F 5 ] + , [MeNC 5 F 4 I] + , and [MeN 3 C 3 F 3 ] + . To gain a better understanding of such fundamental Friedel–Crafts reactions, the role of the dimethylchloronium cation has been evaluated by quantum‐chemical calculations.