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Ruthenium(II)‐Catalyzed Double Annulation of Quinones: Step‐Economical Access to Valuable Bioactive Compounds
Author(s) -
Silva Júnior Eufrânio N.,
Carvalho Renato L.,
Almeida Renata G.,
Rosa Luisa G.,
Fantuzzi Felipe,
Rogge Torben,
Costa Pedro M. S.,
Pessoa Claudia,
Jacob Claus,
Ackermann Lutz
Publication year - 2020
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202001434
Subject(s) - ruthenium , alkyne , annulation , catalysis , combinatorial chemistry , chemistry , double bond , organic chemistry
Double ruthenium(II)‐catalyzed alkyne annulations of quinones were accomplished. Thus, a strategy is reported that provides step‐economical access to valuable quinones with a wide range of applications. C−H/N−H activations for alkyne annulations of naphthoquinones provided challenging polycyclic quinoidal compounds by forming four new bonds in one step. The singular power of the thus‐obtained compounds was reflected by their antileukemic activity.