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Cover Feature: Metallation‐Induced Heterogeneous Dynamics of DNA Revealed by Single‐Molecule FRET (Chem. Eur. J. 22/2020)
Author(s) -
BerrocalMartin Raul,
SanchezCano Carlos,
Chiu Cookson K. C.,
Needham Russell J.,
Sadler Peter J.,
Magennis Steven W.
Publication year - 2020
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202000769
Subject(s) - förster resonance energy transfer , single molecule fret , chemistry , molecule , osmium , dna , single molecule experiment , chemical physics , biophysics , fluorescence , physics , ruthenium , biology , biochemistry , quantum mechanics , organic chemistry , catalysis
The metallation of a DNA hairpin by an organo‐osmium anticancer complex was studied using single‐molecule Förster resonance energy transfer (FRET) microscopy. Ensemble measurements suggested simple, two‐state opening and closing of the hairpin, while single‐molecule experiments revealed complex DNA dynamics which are attributed to different degrees of metallation of the GC‐rich hairpin stem. More information can be found in the Full Paper by P. J. Sadler, S. W. Magennis, et al. on page 4980.