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Cover Feature: Palladium Complexes Based on Ylide‐Functionalized Phosphines (YPhos): Broadly Applicable High‐Performance Precatalysts for the Amination of Aryl Halides at Room Temperature (Chem. Eur. J. 19/2020)
Author(s) -
Tappen Jens,
Rodstein Ilja,
McGuire Katie,
Großjohann Angela,
Löffler Julian,
Scherpf Thorsten,
Gessner Viktoria H.
Publication year - 2020
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202000767
Subject(s) - amination , aryl , halide , ylide , chemistry , palladium , ligand (biochemistry) , catalysis , combinatorial chemistry , coupling reaction , medicinal chemistry , polymer chemistry , organic chemistry , alkyl , biochemistry , receptor
Ylide‐substituted phosphines (YPhos) are excellent ligands for Pd‐catalyzed cross‐coupling reactions. This work examines the impact of different ligand substituents and the use of defined precatalysts on the catalyst activity in room temperature C−N couplings. Increased selectivities and activities are obtained with the backbone‐modified joYPhos ligand which exhibits extremely high activities (TOF>10 000 h −1 ) and productivities for the coupling of a variety of amines and aryl halides. More information can be found in the Full Paper by V. H. Gessner et al. on page 4281.