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Tailor‐Made Amino Acids and Fluorinated Motifs as Prominent Traits in Modern Pharmaceuticals
Author(s) -
Mei Haibo,
Han Jianlin,
White Sarah,
Graham Daniel J.,
Izawa Kunisuke,
Sato Tatsunori,
Fustero Santos,
Meanwell Nicholas A.,
Soloshonok Vadim A.
Publication year - 2020
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202000617
Subject(s) - amino acid , chemistry , structural motif , molecule , identification (biology) , combinatorial chemistry , computational biology , organic chemistry , biochemistry , biology , botany
Structural analysis of modern pharmaceutical practices allows for the identification of two rapidly growing trends: the introduction of tailor‐made amino acids and the exploitation of fluorinated motifs. Curiously, the former represents one of the most ubiquitous classes of naturally occurring compounds, whereas the latter is the most xenobiotic and comprised virtually entirely of man‐made derivatives. Herein, 39 selected compounds, featuring both of these traits in the same molecule, are profiled. The total synthesis, source of the corresponding amino acids and fluorinated residues, and medicinal chemistry aspects and biological properties of the molecules are discussed.