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Enhanced Stability of Peptide Nanofibers Coated with a Conformal Layer of Polydopamine
Author(s) -
Ji Mingyang,
Parquette Jon R.
Publication year - 2020
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202000403
Subject(s) - nanofiber , conformal map , layer (electronics) , conformal coating , peptide , materials science , nanotechnology , chemistry , coating , mathematics , biochemistry , geometry
The susceptibility of self‐assembled materials to changes of environmental conditions and mechanical forces often limits their utility for many applications. In this work, the surface of nanofibers formed by β‐sheet peptide self‐assemblies were coated by polydopamine (PDA) deposition. This conformal coating process rendered the nanofiber dimensions and internal π‐stacking chirality impervious to changes in pH, temperature, and physical processing by spin‐coating onto a silicon wafer. Whereas sonication‐induced shearing of the dopamine/naphthalenediimide–dilysine (DA/NDI–KK) composite irreversibly shortened the nanofibers into 100–200 nm segments, the uncoated nanofibers unraveled into single strands upon similar treatment. Additionally, the PDA‐coated nanofibers could be wrapped by an additional layer comprised of a positively charged polyelectrolyte polymer.